Cerebrovascular Remodeling and Epilepsy
نویسندگان
چکیده
منابع مشابه
Cerebrovascular Remodeling in Epilepsy
The role of the blood-brain barrier (BBB) in epilepsy has evolved from an obstacle for drug brain delivery to an etiological factor contributing to seizures. Recent evidence has shown cerebrovascular angiogenesis and increased BBB permeability in the epileptic foci of patients and in experimental models of seizure. The molecular players involved in cerebrovascular remodeling in the epileptic br...
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Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
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Retinogeniculate connections undergo postnatal refinement in the developing visual system. Here we report that non-ion channel epilepsy gene LGI1 (leucine-rich glioma-inactivated), mutated in human autosomal dominant lateral temporal lobe epilepsy (ADLTE), regulates postnatal pruning of retinal axons in visual relay thalamus. By introducing an ADLTE-associated truncated mutant LGI1 (836delC) or...
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Epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory agents. Dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. In addition, this system undergoes many changes in epileptic brain. Understanding the e...
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Despite remarkable successes in prevention and treatment, hypertension (HTN) remains a major cause of morbidity and mortality worldwide. The brain is one of the preeminent target organs in which high blood pressure is particularly damaging, contributing significantly to its burden of disease. HTN is the biggest risk factor for stroke, the second cause of death worldwide and a major cause of lon...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2012
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858412462747